News for Package NonCompart

Changes in version 0.8.1 (2026-06-20)

• IQNCA added: a self-contained Installation Qualification (IQ) report in pdf documenting whether NonCompart is correctly installed, intact, loadable, and operational (environment, version, dependency satisfaction, MD5 file integrity, namespace/exports, a functional NCA check against an external reference, an overall QUALIFIED/NOT QUALIFIED verdict, a sessionInfo appendix, and a per-file md5 checksum appendix).

• OQNCA added: a self-contained Operational Qualification (OQ) report in pdf. It runs eight WinNonlin-referenced NCA scenarios (shipped in ‘inst/OQ’) through tblNCA on the user's machine and lists every computed value next to its reference value, with the absolute and relative difference and a pass flag, and an overall verdict.

• writeMD5NCA added: writes the standard R ‘MD5’ integrity manifest into an installed package directory (using tools::md5sum) so that the IQNCA file-integrity check reports PASS for local installs. CRAN installs already include this manifest.

• addSigFieldNCA added (and a sigField argument to IQNCA/OQNCA): insert Adobe Acrobat Reader signature fields into the report PDF (pure base-R PDF incremental update, no external tools) so it can be signed with one click in the free Acrobat Reader, instead of printing and scanning.

• signPDFNCA and verifyPDFNCA added: digitally sign a report PDF (a detached SHA-256 signature written to ‘<pdf>.sig’, using the openssl package) and verify it, as a scriptable alternative.

• The IQ and OQ reports use 1 inch margins on every side, select Letter paper in a United States locale and A4 elsewhere, and place the signature/approval page first.

Changes in version 0.8.0 (2026-04-26)

• sNCA and tblNCA support predetermined indices of points (UsePoints) to calculate terminal slope.

Changes in version 0.7.2 (2026-03-27)

• tblNCA supports vector input for dur argument.

Changes in version 0.7.1 (2026-03-09)

• Fixed a bug in Slope where sequential is.finite filtering could cause misaligned x and y vectors.

• Fixed typo 'umul/mL' to 'umol/mL' in concentration unit normalization (Unit, UnitUrine).

• Replaced unsafe eval(parse(text=...)) with direct logical subsetting in tblNCA and tblAUC.

• Extracted duplicated slope-finding logic in BestSlope into helper function findBestSlope.

• Normalized adm parameter once at the top of sNCA instead of calling toupper(trimws()) repeatedly.

• Extracted shared unit conversion helpers (normalizeConcUnit, convertVolUnit) in Unit.R.

• Reduced redundant toupper(trimws(down)) calls in AUC and IntAUC.

Changes in version 0.7.0 (2023-11-15)

• Minor updates.

Changes in version 0.6.0 (2022-07-15)

• SS option for steady-state added in sNCA and tblNCA

• tblAUC, gAUC, gInterpol functions are added for general purpose AUC such as AUC for pharmacodynamic(PD) data.

Changes in version 0.5.1 (2022-06-15)

• Rare cases raising NaN in BestSlope are handled.

Changes in version 0.5.0 (2022-01-20)

• DetSlope no longer opens a new device when closed.

• Data type error with tibble data is fixed.

Changes in version 0.4.9 (2021-07-10)

• Bug when a slope is determined by manual selection is fixed.

• excludeDelta option added to tblNCA, sNCA, and BestSlope functions.

Changes in version 0.4.8 (2021-06-10)

• UT function removed

• returnNA option in sNCA function is removed.

Changes in version 0.4.7 (2020-01-02)

• When it is impossible to determine slope, it skips.

Changes in version 0.4.6 (2020-01-02)

• tblNCA supports iAUC argument.

Changes in version 0.4.5 (2019-09-28)

• Some sentences are revised.

Changes in version 0.4.4 (2018-07-20)

• Nonnumeric Subject ID is supported.

Changes in version 0.4.3 (2018-05-17)

• tblNCA is rewritten.

Changes in version 0.4.2 (2018-05-17)

• Issue on reverse dependence on ncar is solved.

Changes in version 0.4.1 (2018-04-17)

• Validation document is added.

• DetSlope now accepts default slope from BestSlope.

• Errata in manual corrected.

Changes in version 0.4.0 (2018-03-17)

• DetSlope function is added to determine slope manually.

Changes in version 0.3.3 (2017-08-16)

• NonCompart is more tolerable to the input error.

• sNCA can accept key of multiple columns instead of single column colSubj.

Changes in version 0.3.2 (2017-07-19)

• NonCompart can handle the case of no or one positive y value.

Changes in version 0.3.1 (2017-07-10)

• NonCompart A bug in C0 calcuation of IV bolus case was fixed.

Changes in version 0.3.0 (2017-04-06)

• NonCompart Only essential functions for calculation were remained.