SATS: Signature Analyzer for Targeted Sequencing (SATS)

Performs mutational signature analysis for tumors profiled by targeted sequencing. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation count matrix into a panel-context matrix (measuring the number of mutation opportunities per million base pairs for each tumor), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed to each signature, namely the signature burden, for each tumor profiled by targeted sequencing. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>.

Version:	1.0.11
Depends:	R (≥ 4.1.0)
Imports:	stats, glmnet, GenomicRanges, IRanges, Biostrings, dplyr
Suggests:	testthat, BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38
Published:	2026-09-15
DOI:	10.32614/CRAN.package.SATS
Author:	DongHyuk Lee [aut], Bin Zhu [aut], Bill Wheeler [cre]
Maintainer:	Bill Wheeler <wheelerb at imsweb.com>
License:	GPL-2
NeedsCompilation:	yes
CRAN checks:	SATS results

Documentation:

Reference manual:

SATS.html , SATS.pdf

Downloads:

Package source:	SATS_1.0.11.tar.gz
Windows binaries:	r-devel: SATS_1.0.10.zip, r-release: SATS_1.0.10.zip, r-oldrel: SATS_1.0.10.zip
macOS binaries:	r-release (arm64): SATS_1.0.10.tgz, r-oldrel (arm64): not available, r-release (x86_64): SATS_1.0.10.tgz, r-oldrel (x86_64): not available
Old sources:	SATS archive

Linking:

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